September 13, 2021 0 Comments

Download Citation on ResearchGate | Cancer de la ampolla de Vater | The authors report the results of studies on five patients -3 males and 2 females- with . Periampullary tumors are neoplasms that arise in the vicinity of the ampulla of Vater. Neoplasms that arise in this site can originate from the. Metastasis of breast cancer to major duodenal papilla Palabras clave: Ampolla de Vater; Neoplasias de la mama; Ictericia (fuente: DeCS BIREME).

Author: Gugar Fausho
Country: Serbia
Language: English (Spanish)
Genre: Technology
Published (Last): 13 August 2013
Pages: 213
PDF File Size: 12.73 Mb
ePub File Size: 17.65 Mb
ISBN: 837-7-97557-191-6
Downloads: 26597
Price: Free* [*Free Regsitration Required]
Uploader: Gagrel

Locally advanced and metastatic disease Surgery represents the main therapeutic approach vatrr ampullary cancer, whilst unresectable tumors can be treated with either radiotherapy or chemotherapy. Reappraisal of endosonography of ampullary tumors: What did we learn from our study and what suggestions come from the literature?

Support Center Support Center. There is no standard chemotherapeutic regimen for metastatic disease. Surg Oncol Clin N Am.

Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: Carcinoma vtaer the ampulla of Vater is an uncommon tumor. Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: To date, there are no consistent data concerning biliary tree tumors and antiangiogenic drugs and only a few studies concerning anti-epidermal growth factor receptor EGFR drugs.

The area within 2 cm of the ampulla is called periampullary region. The major duodenal papillaseen on duodenoscopy at the time of ERCP.


A gemcitabine plus capecitabine schedule was tested in 45 patients with advanced biliary cancer and no prior chemotherapy[ 67 ]. However, the small sample size of patients with ampullary carcinoma recruited in the ABC 02 study, and lack of other randomized trials, make the optimal treatment for these patients still debatable. Survival after attempted surgical resection and intraoperative radiation therapy for pancreatic and periampullary adenocarcinoma.


A pooled analysis of clinical trials, comprising patients, showed that a single-agent antimetabolite 5FU or gemcitabine is better than any other single drug, as well as that a combined schedule of antimetabolites plus platinum salts is more effective than a single agent or any other doublet[ 56 ], the most promising combinations being gemcitabine plus cisplatin[ 57 ], and gemcitabine plus oxaliplatin[ 58 ].

TX Primary tumor cannot be assessed. Histological examination showed a carcinoma, with infiltration in the duodenal mucosa. The ampulla is 1. Is endosonography an effective method for detection and local staging of the ampullary carcinoma?

Conversely, the survival rate of ampullary cancer with pancreatobiliary differentiation appears to be comparable to that of pancreatic cancer[ 2627 ].

Share cases and questions with Physicians on Medscape consult. The chemotherapic options available for ampullary cancer are also reviewed.

Carcinoma of the Ampulla of Vater. Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancer. Souza 1aJose P. Aust N Z J Surg.

Tumors of ampulla of Vater: A case series and review of chemotherapy options

Gemcitabine and oxaliplatin in advanced biliary tract carcinoma: Histopathology, molecular features and clinical outcome clearly identify two distinct types of ampullary cancer, and their differences should be taken into account both in selecting medical treatments and in planning clinical trials.

Combining gemcitabine and capecitabine in patients with advanced biliary cancer: Associated with such findings, a 15 mm dilatation of the intra and extrahepatic biliary tree was observed by abdominal ultrasound. The assessment and staging of ampullary neoplasms is based on several diagnostic modalities, including extracorporeal ultrasonography UScomputed tomography CTmagnetic resonance cholangiopancreatoscopy, esophagogastro-duodenoscopy, endoscopic US EUSendoscopic-retrograde cholangiopancreatography, intraductal Cancet IDUS and biopsy.


Although metastases of breast carcinomas are infrequent to the gastrointestinal tract, neoplasms of the juxtapapillary region should be suspected, especially at an early stage, since curative resection can be offered.

The role of chemotherapy in advanced biliary cancer was assessed in a study in which palliative chemotherapy achieved survival advantage and improved quality of life when compared with best supportive care[ 55 ].

TX Primary tumor cannot be assessed. Predictors for patterns ampoloa failure after pancreaticoduodenectomy in ampullary cancer.


Noteably, intestinal differentiation confers a statistically significant survival advantage both in periampullary and in ampullary carcinoma, making the survival rate of ampullary cancer similar to that of duodenal cancer[ 27 ]. Peripancreatic lymph nodes are included with the resection.

Biology portal Medicine portal. Eckel F, Schmid RM. Cancers of the liver and biliary tract. Experience with consecutive tumors of the duodenum, ampulla, head of the pancreas, and distal common bile duct. Postoperative radiotherapy does not improve survival.

Due to the peculiar anatomy of the Ampulla of Vater, the early onset of cancer symptoms makes ampullary tumors more likely xe be resected than other pancreatobiliary cancers[ 2 ]. According to the Kimura classification[ 6 ], ampullary cancers were divided in intestinal and pancreatobiliary, depending on their histological differentiation.

Local resection ampullectomy may be considered cander patients with an wmpolla adenoma with absence of dysplasia on preoperative biopsies who are inappropriate candidates for pancreaticoduodenectomy.