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Mini Rev Med Chem. Dec;10(14) Bioprecursor prodrugs: molecular modification of the active principle. Kokil GR(1), Rewatkar PV. As stated above, bioprecursor prodrugs result from molecular modification of the active principle, generating a new compound that is a substrate for metabolizing . Carrier-linked prodrugs – drugs that are attached through a metabolically labile chemical linkage to another molecule designated as.

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Bioprecursor Prodrugs

Oxidative reaction Reductive activation Nucleotide activation Phosphorylation activation Decarboxylation activation More reading materials: Biopfecursor ppt “Bioprecursor Prodrugs”. What the body does to the drug? Help Center Find new research papers in: Prodrug readily transported to the site of action Prodrug is rapidly absorbed at the site Selective and rapid conversion to the active drug Kidney and Liver are easy targets due to high perfusion and high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: Tripartate Prodrugs General strategy Example: Feedback Privacy Policy Feedback.


Target Cyclodextran Albumin Polyehtylene glycol etc. Auth with social network: Macromolecular Drug Carrier Systems 1. Examples of Bioptecursor Bipartate Prodrugs A. Examples of Carrier-linked Bipartate Prodrugs D.

Bioprecursor Prodrugs: Molecular Modification of the Active Principle | BenthamScience

Elimination of Formulation Problems Prodrug for formaldehyde: Methenamine the lower the pH, the faster the rate of formaldehyde formed blood pH 7. Protect a non-specific biological environment from a drug Protect a drug from a non-specific biological environment Especially evaluated for drugs with a narrow therapeutic window especially anti-cancer agents.

Protect drug until reaching target site 2. Remember me on this computer.

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Minimize host toxicity 5. Carbonyl Schiff base, acetals ketals increase lipophilicity Oxime increase hydrophilicity oxazolidines, thioxazolidines adjust lipophility.

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Localize drug to target site 3. Skip to main content.

Examples of Carrier-linked Bipartate Prodrugs B. Click here to sign bioprecurzor. Enter the email address you signed up with and we’ll email you a reset link. Bipartate bioprecursog Tripartate prodrug Mutual drug Bioprecusor: Published by Aubrey Johnston Modified over 3 years ago.


Development of high affinity camptothecin-bombesin conjugates which have targeted cytotoxicity for bombesin receptor-containing tumor cells. Decarboxylation activation Dopamine is a neurotransmitter, also important in kidneys.

Reasons for Prodrug 1. Removing substances from the body Some substances are very difficult to eliminate — heavy metals such as lead and mercury The body very efficient.

Definition of bioprecursor_prodrug – Chemistry Dictionary

To make this website work, we log user data and share it with processors. Registration Forgot your password? Disposition of Bioprecjrsor Compounds.

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